Rabbits are gentle, docile animals that are used in experiments because they breed easily and quickly. Sadly, they also provide a larger amount of sample material per animal than rats or mice.
They are used as bioreactors for antibody production1 and have been the standard animal to test skin and eye irritation of cosmetics and other products.
A well-known rabbit-based test used internationally is the Draize Test, an animal test that is used to try and assess if a substance will cause any eye or skin irritancy in humans by measuring the side effects on animals, normally albino rabbits. This test was developed in the 1940s and is less accurate than animal-free methods.2,3 In the past, we ran a campaign to remove this requirement for the Draize test from NZ law!
Rabbits are also used in medical research to try and model human health conditions to investigate mechanisms and test medications.4
Rabbits are the main animals used for testing chemicals and the production of biological agents (i.e., antibodies) in NZ. Antibodies are a type of cell within the immune system of the body. Many laboratory techniques use antibodies for a range of different tests, for example, biological quality control and toxicity testing. The use of animal-derived antibodies is increasingly questioned, with animal-free antibodies being recommended by the EU Joint Research Centre5.
While many animals are still alive at the end of being used for science, the percentage of rabbits who died or were killed after being used for science has never been below 85% in the last decade.6
Rabbits in NZ have been used for:
- The production of antibodies for laboratory use.
- Drug research, including safety testing.
- Teaching purposes in schools, including for observation and dissection.
- Conservation research, because they are an unwanted species. For example, in 2021, 55,000 rabbits were used in a trial to assess the impact of an experimental formulation containing 1080 in carrot baits.
- Medical research, including for testing surgical procedures and imaging equipment. Rabbits are also used to try and model human conditions (i.e., glaucoma, heart failure and sinusitis).
- Basic biological research into how vital signs change during intercourse, bones grow and the digestive tract moves.
Places that use rabbits for science in NZ include private companies, universities, and polytechnics.
Rabbits used for science in NZ are sourced from breeding units, farms, the wild (captured), commercial sources and other public sources.*
*According to the Ministry for Primary Industries, public sources include: Public donations, animals obtained from a pound, a pet shop or other public sources. This includes companion animals who are used for the duration of the exercise (e.g. veterinary nurse training).
Discover real-life examples of how rabbits have been used in NZ below!
Testing the welfare impact of pindone toxin
Three groups of young NZ White Rabbits received pindone-toxin pellets on different schedules. Any rabbit still alive after three weeks was killed.
Measuring jaw bone growth in young rabbits
Young rabbits were anaesthetised and had holes drilled into their jawbones to implant small pieces of metal. X-ray scans were made, and the rabbits were killed.
Testing new drug formulations
Rats and rabbits were injected with a new anaesthetic, pinching their paw repeatedly to measure reflexes. Rats were giving the medication until they died.
Teaching animal researchers
A range of animals is used to teach researchers handling and experimental methods.
Injuring the sinus tract to test medication
NZ White rabbits were anaesthetised, and the sinus tracts in their nose were purposely injured to the bone. Two weeks after treatment, they were killed.
Infecting rabbits with a virus to have more samples of it
Samples of dead wild rabbits were taken to collect virus material. The virus was then used to infect rabbits and analyse their tissue.
Testing new drug formulations
NZ White rabbits were given a new drug formulation or ketamine. Righting reflex, paw withdrawal, and blood parameters were checked every minute.
Using rabbits as a model for human atherosclerosis
NZ White rabbits were fed pellets with or without added cholesterol for 10 weeks. They were killed with anaesthetic and taking blood from their heart until it stopped.
Harvesting rabbit caecum for more lab tests
Domestic dwarf rabbits were anaesthetised, their caecum was cut out, and then they were killed.
Taking blood samples over several days
Two New Zealand white rabbits were anaesthetised and restrained. Catheters were put into their ear veins to inject a solution and take regular blood samples.
Placing metal into rabbits’ jaws
NZ White rabbits were anaesthetised, and metal spheres were placed into their jaws. X-rays were taken to measure bone growth.
Testing a new drug delivery formulation
NZ White rabbits were injected with a radioactive solution, wrapped tightly, and recorded this way for 90min.
Testing the behaviour of a drug in rabbits’ blood
NZ White rabbits were infused with different medications, and blood samples were taken regularly for 24 hours.
Harvesting rabbit caecum for lab tests
Domesticated rabbits were anaesthetised. Part of their digestive tract was removed, and then they were killed.
Monitoring vital signs of rabbits during intercourse
NZ White rabbits were anaesthetised and implanted with devices to measure vital signs. They were then monitored during intercourse.
Using rabbits as glaucoma surgery model
The eyes of NZ White rabbits were surgically opened and treated with different solutions. At intervals, some were killed to analyse the eye tissue.