Rabbits are gentle, docile animals that are used in experiments because they breed easily and quickly. Sadly, they also provide a larger amount of sample material per animal than rats or mice.
They are used as bioreactors for antibody production1 and have been the standard animal to test skin and eye irritation of cosmetics and other products.
A well-known rabbit-based test used internationally is the Draize Test, an animal test that is used to try and assess if a substance will cause any eye or skin irritancy in humans by measuring the side effects on animals, normally albino rabbits. This test was developed in the 1940s and is less accurate than animal-free methods.2,3 In the past, we ran a campaign to remove this requirement for the Draize test from NZ law!
Rabbits are also used in medical research to try and model human health conditions to investigate mechanisms and test medications.4
Rabbits are the main animals used for testing chemicals and the production of biological agents (i.e., antibodies) in NZ. Antibodies are a type of cell within the immune system of the body. Many laboratory techniques use antibodies for a range of different tests, for example, biological quality control and toxicity testing. The use of animal-derived antibodies is increasingly questioned, with animal-free antibodies being recommended by the EU Joint Research Centre5.
While many animals are still alive at the end of being used for science, the percentage of rabbits who died or were killed after being used for science has never been below 85% in the last decade.6
Rabbits in NZ have been used for:
- The production of antibodies for laboratory use.
- Drug research, including safety testing.
- Teaching purposes in schools, including for observation and dissection.
- Conservation research, because they are an unwanted species. For example, in 2021, 55,000 rabbits were used in a trial to assess the impact of an experimental formulation containing 1080 in carrot baits.
- Medical research, including for testing surgical procedures and imaging equipment. Rabbits are also used to try and model human conditions (i.e., glaucoma, heart failure and sinusitis).
- Basic biological research into how vital signs change during intercourse, bones grow and the digestive tract moves.
Places that use rabbits for science in NZ include private companies, universities, and polytechnics.
Rabbits used for science in NZ are sourced from breeding units, farms, the wild (captured), commercial sources and other public sources.*
*According to the Ministry for Primary Industries, public sources include: Public donations, animals obtained from a pound, a pet shop or other public sources. This includes companion animals who are used for the duration of the exercise (e.g. veterinary nurse training).
Discover real-life examples of how rabbits have been used in NZ below!
Investigating intestine movements
Young pigs and NZ White rabbits were anaesthetised. A part of their intestine was pulled out far enough to record its movements and signalling.
Harvesting eyes for lab tests
The eyes of pigs and rabbits killed for experiments were used to analyse the structure of the cornea.
Testing a new vaccine
NZ White rabbits were injected with a new vaccine type several times before being killed.
Causing sinusitis in rabbits as a model
NZ White rabbits were anaesthetised, and a sinus tract in their nose was blocked for four weeks to cause sinusitis. After another ten weeks with regular samples, they were killed.
Harvesting rabbit and pig eyes for lab tests
The eyes of slaughtered rabbits and pigs killed for experiments were used to analyse the structure of the cornea.
Using a new imaging technology
One NZ White rabbit and rats were killed, and their eyes were removed to use for the study.
Testing the toxicity of some substances
Young NZ White rabbits were force-fed different doses of toxic substances. Blood samples were taken before and immediately after killing them at set time points (or to end their suffering).
Mapping wave patterns of the small intestine
NZ White rabbits were anaesthetised, their intestines were used for electrode mapping, and then they were killed.
Measuring contractions in exposed rabbit uteruses
Pregnant rabbits were anaesthetised, and their uterus was exposed. Measurements were taken while contraction-inducing injections were given. Then they were all killed for dissection.
Using muscles of dead rabbits for imaging
Two NZ White rabbits were killed to use for detailed muscle imaging.
Testing an antimicrobial eye medication
NZ White rabbits were treated with Manuka honey solution in one eye and a control solution in the other eye for five days. Different values like tearing and irritation were measured.
Harvesting rabbit bladders for lab tests
NZ White rabbits were anaesthetised, their bladder was cut out, and then they were killed.
Harvesting rabbit colons for lab tests
NZ White rabbits were anaesthetised, a part of their intestine was cut out, and then they were killed.
Studying presence of a virus in rabbits
Wild rabbits were shot, caught by dogs or trapped to test them for virus strains. The infectious solution was then fed to NZ White rabbits in a lab to kill them later.
Testing new formulations of eye medication
The eyes of albino rabbits were treated with different medications. At regular intervals, several of them were killed.
Testing efficiency of strip-sowing 1080 bait
The toxin ‘1080’ was distributed as complete coverage and in a strip pattern. Effects on the wild rabbit numbers were evaluated.